Structural Aspects of GPCR-G Protein Coupling
نویسندگان
چکیده
منابع مشابه
Structural Aspects of GPCR-G Protein Coupling
G protein-coupled receptors (GPCRs) are membrane receptors; approximately 40% of drugs on the market target GPCRs. A precise understanding of the activation mechanism of GPCRs would facilitate the development of more effective and less toxic drugs. Heterotrimeric G proteins are important molecular switches in GPCR-mediated signal transduction. An agonist-activated receptor interacts with specif...
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G-protein coupled receptors (GPCRs) bind with G-proteins upon activation by ligands. Understanding the mechanisms of specific binding between GPCRs and G-proteins is one of the most important issues in bioinformatics research. In this study, the physical properties of various regions were analyzed in order to classify GPCRs by G-protein family and to better understand binding specificity. We fo...
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ژورنال
عنوان ژورنال: Toxicological Research
سال: 2013
ISSN: 1976-8257
DOI: 10.5487/tr.2013.29.3.149